Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary Targetglycolipid synthesis in cultured NIH/3T3 cells

General description

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured NIH/3T3 cells.

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and is a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured 3T3 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Rani, C.S., et al. 1995. J. Biol. Chem. 270, 2859.Rosenwald, A.G. 1992. Biochemistry31, 3581.Inokuchi, J., and Radin, N.S. 1987. J. Lipid Res.28, 565.Vunnam, R.R., and Radin, N.S. 1980. Chem. Phys. Lipids26, 265.

Packaging

50 mg in Plastic ampoule

Warning

Toxicity: Irritant (B)